Jag kkar det dagligen, har inte mrkt ngon skillnad men frn vad man lst s: "Decreases in NAD+ have been shown as a feature of aging and may play a role in the process".
"Low NAD+ contributes to aging because NAD+ serves as an exclusive co-substrate for two key families of enzymes that affect cellular repair and longevitythe sirtuins (SIRTs) and the poly(ADP-ribose) polymerases (PARPs). These enzyme families regulate many signaling processes associated with cellular health and longevity and are directly dependent on NAD+ availability to perform their functions."
"Human trials so far have shown that NAD+ supplementation may improve exercise performance in older adults, Increase insulin sensitivity, and provide anti-inflammatory effects"
"In animal models, studies have shown that stimulating NAD+ with NMN or NR can extend healthspandefined as years lived in good healthand reduce premature aging, according to Renae Thomas, MD, MPH, a physician certified in family medicine, public health, and general preventive medicine."
S frhoppningsvis gr det ngot i kroppen iaf
"our NAD+ levels naturally decline. By the time were 40, levels have dipped by 50% and by age 60, the NAD+ dip has jumped to 80%."
https://nadclinic.com/nad-decline-si...n-middle-aged/
"Low NAD+ contributes to aging because NAD+ serves as an exclusive co-substrate for two key families of enzymes that affect cellular repair and longevitythe sirtuins (SIRTs) and the poly(ADP-ribose) polymerases (PARPs). These enzyme families regulate many signaling processes associated with cellular health and longevity and are directly dependent on NAD+ availability to perform their functions."
"Human trials so far have shown that NAD+ supplementation may improve exercise performance in older adults, Increase insulin sensitivity, and provide anti-inflammatory effects"
"In animal models, studies have shown that stimulating NAD+ with NMN or NR can extend healthspandefined as years lived in good healthand reduce premature aging, according to Renae Thomas, MD, MPH, a physician certified in family medicine, public health, and general preventive medicine."
S frhoppningsvis gr det ngot i kroppen iaf
"our NAD+ levels naturally decline. By the time were 40, levels have dipped by 50% and by age 60, the NAD+ dip has jumped to 80%."
https://nadclinic.com/nad-decline-si...n-middle-aged/
__________________
Senast redigerad av Huhaenihi 2024-12-28 kl. 21:12.
Senast redigerad av Huhaenihi 2024-12-28 kl. 21:12.
Citat:
Jag kkar det dagligen, har inte mrkt ngon skillnad men frn vad man lst s: "Decreases in NAD+ have been shown as a feature of aging and may play a role in the process".
"Low NAD+ contributes to aging because NAD+ serves as an exclusive co-substrate for two key families of enzymes that affect cellular repair and longevitythe sirtuins (SIRTs) and the poly(ADP-ribose) polymerases (PARPs). These enzyme families regulate many signaling processes associated with cellular health and longevity and are directly dependent on NAD+ availability to perform their functions."
"Human trials so far have shown that NAD+ supplementation may improve exercise performance in older adults, Increase insulin sensitivity, and provide anti-inflammatory effects"
"In animal models, studies have shown that stimulating NAD+ with NMN or NR can extend healthspandefined as years lived in good healthand reduce premature aging, according to Renae Thomas, MD, MPH, a physician certified in family medicine, public health, and general preventive medicine."
S frhoppningsvis gr det ngot i kroppen iaf
"our NAD+ levels naturally decline. By the time were 40, levels have dipped by 50% and by age 60, the NAD+ dip has jumped to 80%."
https://nadclinic.com/nad-decline-si...n-middle-aged/
"Low NAD+ contributes to aging because NAD+ serves as an exclusive co-substrate for two key families of enzymes that affect cellular repair and longevitythe sirtuins (SIRTs) and the poly(ADP-ribose) polymerases (PARPs). These enzyme families regulate many signaling processes associated with cellular health and longevity and are directly dependent on NAD+ availability to perform their functions."
"Human trials so far have shown that NAD+ supplementation may improve exercise performance in older adults, Increase insulin sensitivity, and provide anti-inflammatory effects"
"In animal models, studies have shown that stimulating NAD+ with NMN or NR can extend healthspandefined as years lived in good healthand reduce premature aging, according to Renae Thomas, MD, MPH, a physician certified in family medicine, public health, and general preventive medicine."
S frhoppningsvis gr det ngot i kroppen iaf
"our NAD+ levels naturally decline. By the time were 40, levels have dipped by 50% and by age 60, the NAD+ dip has jumped to 80%."
https://nadclinic.com/nad-decline-si...n-middle-aged/
Skrp dig - s klart de skriver det r bra nr de tjnar pengar p att slja det. r du hyfsat normalfrisk och inte r p nn jttekonstig diet producerar din kropp precis lagom av NAD(H) alldeles av sig sjlv.
Citat:
Jag kkar det dagligen, har inte mrkt ngon skillnad men frn vad man lst s: "Decreases in NAD+ have been shown as a feature of aging and may play a role in the process".
"Low NAD+ contributes to aging because NAD+ serves as an exclusive co-substrate for two key families of enzymes that affect cellular repair and longevitythe sirtuins (SIRTs) and the poly(ADP-ribose) polymerases (PARPs). These enzyme families regulate many signaling processes associated with cellular health and longevity and are directly dependent on NAD+ availability to perform their functions."
"Human trials so far have shown that NAD+ supplementation may improve exercise performance in older adults, Increase insulin sensitivity, and provide anti-inflammatory effects"
"In animal models, studies have shown that stimulating NAD+ with NMN or NR can extend healthspandefined as years lived in good healthand reduce premature aging, according to Renae Thomas, MD, MPH, a physician certified in family medicine, public health, and general preventive medicine."
S frhoppningsvis gr det ngot i kroppen iaf
"our NAD+ levels naturally decline. By the time were 40, levels have dipped by 50% and by age 60, the NAD+ dip has jumped to 80%."
https://nadclinic.com/nad-decline-si...n-middle-aged/
"Low NAD+ contributes to aging because NAD+ serves as an exclusive co-substrate for two key families of enzymes that affect cellular repair and longevitythe sirtuins (SIRTs) and the poly(ADP-ribose) polymerases (PARPs). These enzyme families regulate many signaling processes associated with cellular health and longevity and are directly dependent on NAD+ availability to perform their functions."
"Human trials so far have shown that NAD+ supplementation may improve exercise performance in older adults, Increase insulin sensitivity, and provide anti-inflammatory effects"
"In animal models, studies have shown that stimulating NAD+ with NMN or NR can extend healthspandefined as years lived in good healthand reduce premature aging, according to Renae Thomas, MD, MPH, a physician certified in family medicine, public health, and general preventive medicine."
S frhoppningsvis gr det ngot i kroppen iaf
"our NAD+ levels naturally decline. By the time were 40, levels have dipped by 50% and by age 60, the NAD+ dip has jumped to 80%."
https://nadclinic.com/nad-decline-si...n-middle-aged/
Djurstudier och de sm studier som gjordes p vissa mnskliga celler (t ex hud) i brjan av 2000-talet pekade p avsevrd avtagande niver. Mer kompletta studier p mnniska har givit en mycket mer komplex bild, dr signifikant avtagande inte r tydligt (t ex har spdbarn hga niver i huden men de avtar snabbt). Se t ex https://www.mdpi.com/2072-6643/14/1/101. Sklart de som sljer tillskott inte har med sdana studier.
Citat:
Glm resveratrol. De effekter p sirtuinaktivitet man sg i David Sinclairs nu diskrediterade studier visade sig vara specifika fr den fluorescerande probe de anvnde fr att mta aktiviteten. Det finns inte heller ngra trovrdiga data som visar p ngon positiv effekt av resveratrol i mnniskor, vare sig p ldrandet eller i vrigt.
Vad gller vitamin B3 och dess olika derivat, som NMN, s gller fljande:
1. Olika former av vitamin B3 bryts snabbt ner till nikotinsyra (niacin) av tarmbakterierna, som sedan tas upp av tarmen. Det innebr att om du petar i dig dyra derivat som NMN (ven det torgfrt av David Sinclair och hans fretag) s har det sannolikt samma effekt som den mycket billigare nikotinsyran.
2. Du kan hja blodnivn av NAD genom att ta stora doser av vitamin B3, men det finns inga trovrdiga studier som visar p ngon positiv effekt av det, i vart fall inte hos friska mnniskor. Tvrtom s finns det studier som talar fr en kad ddlighet i hjrt- och krlsjukdomar vid intag av stora doser (1-3 g/dag) av vitamin B3.
3. Nivn av NAD i musklerna kar inte bara drfr att nivn i blodet kar, vilket kan frklara varfr de positiva effekterna av ett kat intag uteblir. Musklerna och andra vvnader teranvnder sitt NAD och fyller bara p med precis s mycket som behvs frn blodet, t.ex. vid kat fysiskt arbete.
4. Ett verskott av NAD i blodet bryts i stllet ned till toxiska metaboliter som 4PY, vilket kan vara en orsak till den kade ddligheten i hjrt- och krlsjukdomar:
A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
https://www.nature.com/articles/s41591-023-02793-8
Metabolic product of excess niacin is linked to increased risk of cardiovascular events
https://www.nature.com/articles/s41569-024-01005-1
Vad gller vitamin B3 och dess olika derivat, som NMN, s gller fljande:
1. Olika former av vitamin B3 bryts snabbt ner till nikotinsyra (niacin) av tarmbakterierna, som sedan tas upp av tarmen. Det innebr att om du petar i dig dyra derivat som NMN (ven det torgfrt av David Sinclair och hans fretag) s har det sannolikt samma effekt som den mycket billigare nikotinsyran.
2. Du kan hja blodnivn av NAD genom att ta stora doser av vitamin B3, men det finns inga trovrdiga studier som visar p ngon positiv effekt av det, i vart fall inte hos friska mnniskor. Tvrtom s finns det studier som talar fr en kad ddlighet i hjrt- och krlsjukdomar vid intag av stora doser (1-3 g/dag) av vitamin B3.
3. Nivn av NAD i musklerna kar inte bara drfr att nivn i blodet kar, vilket kan frklara varfr de positiva effekterna av ett kat intag uteblir. Musklerna och andra vvnader teranvnder sitt NAD och fyller bara p med precis s mycket som behvs frn blodet, t.ex. vid kat fysiskt arbete.
4. Ett verskott av NAD i blodet bryts i stllet ned till toxiska metaboliter som 4PY, vilket kan vara en orsak till den kade ddligheten i hjrt- och krlsjukdomar:
A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
https://www.nature.com/articles/s41591-023-02793-8
Metabolic product of excess niacin is linked to increased risk of cardiovascular events
https://www.nature.com/articles/s41569-024-01005-1
Tack!!! Det var mycket information och jag skall begrunda detta. Angende resveratrol dricker jag rdvin vid varje rymdventyr...
....Men jag skall studera den information du lmnade mycket noga.
Citat:
En lyckad flight 8 med Starship kan vara vrd en flaska gott rdvin. Observera dock att du mste dricka 2000 liter rdvin per dygn fr att komma upp i samma koncentrationer av resveratrol som David Sinclair anvnde i sina frsk.
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