Tillverka MDMA

Förlåt för att jag skriver i en sådan gammal tråd men om någon där ute är intresserad i att göra mdma så skriv gärna en tråd om hur man gör det. Har hört att det ska vara svårt, jag kan inte mycket själv om tillverkning av kemiska droger men funderar på om jag skulle kunna ge mig fan på att lära mig det.
Om någon skulle pluggat kemi och rent tekniskt sett är kapabel till att tillverka mdma så skriv till mig för jag är intresserad i att lära mig.

Numera finns det en egen forumdel för dylikt.

Kemi och pyroteknik --> Drogodling och drogtillverkning
/Moderator

Det är jätte lätt och vem som helst kan göra det i köket så länge du har en Elvisp och en stor kastrull.

Bara följd det här receptet för 3,5 kg MDMA :

General
Reactions were performed using commercially available raw materials and solvents. Unless otherwise stated, all commercially obtained reagents were qualified prior to use and then used as received. Reactions were conducted in a 50 L reaction vessel. The small-scale production of the Grignard reagent, used to initiate the bulk reaction, was conducted in a 2 L reactor fitted with a reflux condenser. A Huber Unistat was used for temperature control and logging. In-process analysis was conducted by HPLC, with supplemental 1H NMR analysis used to quantify residual solvent content during evaporation steps. A wiped-film evaporator was used for distillation. All processes were conducted under nitrogen (target: <5% O2). Residual solvent testing was performed on an Agilent J&W DB-624 HRGC column (60 m × 0.32 mm, 1.80 μm film thickness).
Stage 1─Synthesis of 1-(3,4-Methylenedioxyphenyl)-2-propanol

Grignard Formation

Into a 2 L vessel was charged 16.6 g of magnesium turnings (0.68 mol, 1.1 equiv), followed by 500 mL of THF (181 ppm H2O by KF titration) at 20 °C. Stirring was initiated after the introduction of THF, and the vessel was heated to a gentle reflux. To the vessel was then charged 125 g of 5-bromo-1,3-benzodioxole (0.62 mol, 1 equivalent chemical purity >98.70% by HPLC) in two unequal portions. The first portion weighed 6.3 g and was stirred for 12 h at a gentle reflux until an exotherm was observed. Following this initiation step, the remaining 118.4 g was added, dropwise, to the reaction vessel, and the resultant Grignard solution was stirred at reflux for 40 min and then cooled to 25 °C.
Into a separate 50 L reaction vessel was charged 1.06 kg of magnesium turnings (44 mol; 1.1 equiv) and 32 L of THF. The suspension was stirred and then heated to a gentle reflux. To the reaction vessel was then added 400.0 g of 5-bromo-1,3-benxodioxole (2.0 mol), followed by 400 mL of the small-batch Grignard solution described above. Reflux was maintained. After 5 min, a significant increase in the reflux rate was observed in the glass condenser, indicating initiation. While maintaining reflux, 7.6 kg of 5-bromo-1,3-benxodioxole (38 mol) was then added to the reaction vessel, using a dropping funnel, and the batch was stirred at a gentle reflux for 40 min.
Addition to Propylene Oxide

The bulk Grignard solution was cooled to 10 °C, and 128.8 g of copper iodide (1.5 mol, 0.4 equiv) was added to the 50 L vessel. A solution of 2.5 L (±)-propylene oxide (37 mol, 0.93 equiv) in 2.5 L of THF was then added to the reaction vessel while maintaining the temperature at 0–10 °C. The container and dropping funnel were rinsed with an additional 800 mL of THF, which was then added to the 50 L reaction vessel. The batch was stirred for 40 min at 5–20 °C, forming a dark brown solution and a crystalline suspension. Completion analysis performed by HPLC confirmed the reaction end point (0.30% 5-bromo-1,3-benzodioxole; target limit was ≤1%).
The batch was then divided into two 20.4 L portions for workup. For each portion, 5.45 L of a 10% (w/w) sodium chloride solution, followed by 1.37 L of acetic acid, was added to the 50 L reaction vessel while maintaining the temperature at 10–25 °C. The half-batch portion was then transferred from carboy into the reaction vessel while ensuring that the temperature remained below 40 °C. Following this addition, the half-batch portion was stirred at 30–40 °C for 45 min; then, the pH was adjusted to <5 by sequential addition of three 200 mL of aliquots of acetic acid. The batch was allowed to settle, and the aqueous layer was removed. 8.2 L of n-heptane were then charged into the 50 L reaction vessel, followed by an additional 8 L of the sodium chloride solution. The batch was stirred and allowed to settle, and the aqueous layer was again removed. The dark brown organic layer was filtered over a vacuum, using a plate filter with a 11 μm filter mesh. Following workup, the two half-batches were combined, and the solvent was removed in a 20 L rotatory evaporator. The crude yield was 7442.7 g and analysis by 1H NMR revealed 2.5% residual THF (n-heptane not detected; target limit is ≤10% total amount of both solvents).
The crude product was charged with 1488.5 g of PEG400 (0.2 equiv w/w) and mixed to ensure homogeneity. This mixture was then distilled at 150–185 °C and 0.1–1.5 mbar, using a wiped-film evaporator. Two passes yielded 6293.2 g of a pale yellow oil (94.2% yield; 96.44% area, 89.78% w/w by HPLC).

Stage 2─Oxidation to 1-(3,4-Methylenedioxyphenyl)-propan-2-one

A 50 L reaction vessel was charged with 2760.1 g of crude 1-(3,4-methylenedioxyphenyl)-2-propanol from Stage 1 (88.56% w/w by HPLC assay; active charge is 2444.3 g, 13.6 mol, 1 equivalent) and 9780 mL of dichloromethane at 10–25 °C. Stirring was initiated, and 178.5 g of potassium bromide was added, followed by 233.2 g of TEMPO (0.11 equiv). The batch was cooled to 0 °C, and 7280 mL (60%) of a solution of sodium hydrogen carbonate (0.25 equiv) in 12120 mL of bleach (1.6 equiv, diluted to 12.5% w/v) was added, dropwise, while stirring efficiently and maintaining the temperature at −10 to 10 °C. A 1 mL of sample was then removed, for analysis by HPLC, and four additional 610 mL (5%) of aliquots of the NaHCO3/bleach solution were then added, dropwise, to the reaction vessel. A sample was collected after each addition, and HPLC analysis was used to monitor the reaction progress. After the fourth aliquot was added, 1.61% of Stage 1 starting material remained (target limit is ≤5%). Stirring was halted, and the layers were allowed to settle. The layers were separated, and the organic layer was returned to the 50 L vessel.
For workup, the organic layer was cooled to 0 °C, and 4890 mL of a 12% (w/w) solution of aqueous sodium hydrosulfite was added while maintaining the temperature at 0–10 °C. The reaction mixture was then warmed to 19.5 °C and stirred for 15 min. The layers were separated, and the organic layer was returned to the 50 L reaction vessel. Then, 4900 mL of freshly prepared 0.5 M aqueous NaOH was added, and the reaction mixture was stirred for 15 min. The layers were separated, and the brown organic layer was returned to the 50 L reaction vessel. To this were added 4900 mL of 11% (w/w) aqueous NaCl, followed by 98 mL of concentrated HCl 36% w/w aqueous solution. After stirring for 15 min at 18.5 °C, the layers were separated, and the organic layer was returned to the reaction vessel. Two more washes─the first with another 4900 mL of the 11% NaCl solution, the second with 4900 mL of a saturated NaCl solution─were completed, following the same procedure. The organic layer was filtered over a Buchner funnel fitted with a filter cloth rinsing with 500 mL of DCM and then transferred to a 20 L rotatory evaporator. The solvent was removed under vacuum, yielding 2442.1 g of a yellow-to-brown oil (101.0% crude yield; 94.52% peak area, 89.80 w/w by HPLC).
Stage 3─Reductive Amination to MDMA·HCl

Next, 2963.9 g of crude 1-(3,4-methylenedioxyphenyl)-propan-2-one from Step 2 (13.7 mol, 81.26% w/w by HPLC) was added to a 50 L reaction vessel with 31170 mL of methanol (Kimia, confirmed by FT-IR), and the temperature was lowered to 5 °C. Then, 3520 mL of 40% (w/w) aqueous methylamine (102 mol, 7.5 equiv) was added, dropwise, and the batch was then cooled to −10 °C. To the reaction vessel was added 40.4 g of NaOH (1 mol) and 286.4 g of NaBH4 (7.6 mol, 0.5 equiv) in 630 mL of purified water, over the course of 120 min. The clear brown solution was then warmed to 3.9 °C and stirred for 25 min. A sample was removed and submitted for completion analysis by HPLC; the peak area for the product was 81.04%, and the starting material was undetected, which met the completion threshold of ≤1%. Then, 9640 mL of purified water was added to the reaction vessel, portionwise, while maintaining the temperature at 0–10 °C. The mixture was transferred to a 20 L rotatory evaporator, and methanol was removed, under vacuum. A sample was submitted for analysis, and 1H NMR indicated ≤10% residual methanol, which met the specification.

The crude product was returned to the 50 L reaction vessel and then stirred with 12 100 mL TBME for 15 min at 18.6 °C. The layers were then separated, and the aqueous layer was washed with an additional 2400 mL of TBME. The organic layers were then combined in the 50 L reaction vessel; 12 000 mL of 2.0 M HCl was added portionwise, and the mixture was stirred for 20 min at 15–30 °C. At this point, the pH was 1 (target is 1–2), and layers were again separated. The lower, aqueous layer was returned to the 50 L flask, washed with 12000 mL of TBME and then stirred for 15 min with 6000 mL of 5.4 M aqueous NaOH. Another 12 000 mL of TBME was then added, along with 1589.6 g of Rochelle Salt, and the mixture was stirred for 120 min. The pale brown/orange organic layer was separated from the aqueous layer, and the aqueous layer was washed again with 12 000 mL of TBME. The organic layers were combined, and the solvent was removed, in batches, with a 20 L rotatory and evaporator. Two thousand four hundred milliliters of isopropanol were added to the residue, then removed by a rotatory evaporator. The crude weight of the product (MDMA-free base) was 2524.0 g (94.57% peak area by HPLC).
The crude MDMA was then returned to the 50 L flask, along with 20 280 mL of 2-propanol. Stirring was initiated, and 2435 mL 5.4 M HCl in 2-propanol (13.1 mol) was added, dropwise, over 120 min. The mixture was then stirred for an additional 30 min, at room temperature. The white precipitate was captured via vacuum filtration, on a plate filter fitted with a filter cloth. The filter cake was washed twice with 2-propanol (2500 mL) and then dried under vacuum (100 mbar) for 18 h at 57.3 °C. After drying, 2280.4 g of crude MDMA·HCl remained (73.4% unadjusted yield, 99.26% peak area by HPLC).

Stage 4─Recrystallization of MDMA·HCl

To a 50 L reaction vessel was added 4107.3 g of crude MDMA·HCl and 41 000 mL of 2-propanol. The batch temperature was increased to 67.2 °C, while stirring, and the mixture was then stirred for 30 min at 67.2 °C until all of the solids dissolved. Stress tests had demonstrated stability for 72 h at 70–80 °C proving the thermal stability of MDMA·HCl.
The batch was then transferred through a 1.2 μm in-line filter capsule, using positive pressure, to a clean, 50 L reaction vessel, fitted with a jacket that had been preheated to 66.1 °C. In this new reaction vessel, the batch was cooled to 55.3 °C, over the course of 90 min. Then, 41.1 g of MDMA·HCl Form 1 seed crystal (0.18 mol, 0.008 equiv) was added, and the batch was stirred at the same temperature for 30 min. The batch was cooled to 15.2 °C at a rate of 3 °C/h and then stirred at this temperature for an additional 10 h.
The white suspension was removed from the mother liquor via vacuum filtration over a filter plate fitted with a filter cloth and then washed with 8220 mL of 2-propanol. The filter cake was transferred to a drying oven and dried under vacuum (140 mbar) for 19 h at 56.6 °C. The collected MDMA·HCl was a white solid weighing 3548.3 g (85.5% yield; 99.95% peak area, 99.64% w/w by HPLC). No single impurity exceeded 0.02% of the peak area by HPLC, and residual solvents (methanol, <6 ppm; 2-propanol, 490 ppm) were found to be within the target range.

https://pubs.acs.org/doi/10.1021/acsomega.1c05520#

Tack så jättemycket

Eeh elvisp och kastrull? Varning för detta receptet inkluderar en sk reflux condenser i början, inte alls möjligt med en elvisp i farten. Möjligtvis är detta ett troll svar och att göra detta hemma i lägenheten med en elvisp kan resultera i död även för utomstående. Rekomenderar Strikes gamla böcker, forumet TheHive. Kolla thepiratebay för PDF:er t ex. MDMA är livsfarligt att framställa utan ett fläktskåp till att börja med. Och ska aldrig ske i lägenheter.

Herregud vad pengar det finns i mdma med denna syntes ist för att köra från safrole. Prekursorn är svinbillig i jämförelse. Inte konstigt att priset på mdma gick ner så kraftigt när safrolrötterna tog slut. Dock verkar safrole metoden mycket enklare och inte behöva lika mycket svindyr och licensbelagd utrustning.

Det är en legitim syntes. Tror han var ironisk med tanke på att det är en allt annat än enkel syntes och killen som.frågade efter den verkar vara typ 15 bast.

Joo möjligtvis en oseriös frågan men tråkigt när det kommer oseriösa svar i en potentiell diskussion. Har inte läst syntesen helt och hållet men en elvisp lät lite farligt.

Om någon vill läsa gamla "recept" så finns det två böcker som är rätt bra.

Total Synthesis II - av Strike
Secret of clandestine methamphetamine Manufacture - av Uncle Fester

Den sistnämnda är med fokus för metamfetamin, men många synteser av metamfetamin och mdma är likadana, bara annorlunda proportioner av fenylacetonet/3.4-fenylac... antar jag.

Hursomhelst så inleder Strike iallafall rätt okej med grunderna i kemin som är bra att veta, framförallt hur och var man arbetar på ett sätt som inte är livsfarligt.

Uncle fester är förövrigt lite tokig, han tycker man kan reagera kemikalier under tryck i champagneflaskor i en sektion, inget att rekomendera tydligen av vissa andra.

Strike har även åkt fast under inspelning i TV för att ha sålt kemikalier i ett företag, https://en.wikipedia.org/wiki/Hobart_Huson - lite intressant läsning/tittning

Okej så du tror han skrev så för att han var ironisk lol. Vet inte hur man framställer MDMA, hur det skulle göra mig till 15 år begriper jag inte.
Det verkar vara farligt att göra, det står ute på nätet att man helst ska göra det i ett laboratorium.
Är det någon som gjort MDMA som vet hur svårt det är att tillverka?

Ett exempel på att man kan göra det hemma: The CCB unit of Anti-Narcotics Wing officials busted another international drug racket and arrested a 38-year-old Nigerian National who is preparing MDMA crystals at the lab in his rented house in Electronic city,pedaling across the country and even to New zealand.
https://www.countryandpolitics.in/20...-crore-seized/

Om du behöver fråga hur man framställer MdMA så är det definitivt för svårt för dig.