"Administration of MDMA to dogs and monkeys also produces a spectrum of signs
characteristic of sympathomimetic stimulation including mydriasis, salivation, piloerection and hyperthermia (Hardman et al., 1973; Frith et al., 1987)."
"In high doses, MDMA may cause convulsions in rats, dogs and monkeys (Hardman et al., 1973; Frith et al., 1987; Gordon et al., 1991). Routine necropsy of dogs treated orally with MDMA (15 mg/kg) for 28 days revealed testicular atrophy and prostatic hypertrophy (Frith et al., 1987). The LD50 of MDMA in mice has been estimated between 80-115 mglkg (Hardman et al.., 1973; Davis, Hatourn & Waters, 1987) and is enhanced upon aggregation, characteristic of amphetamine-like compounds (Davis et al., 1987)"
hmtat frn:
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